Table 1 Clinical characteristics.
From: Alterations in the kallikrein-kinin system predict death after heart transplant
Died | Survived | p-value | Multivariate p-value | |
|---|---|---|---|---|
N | 22 | 66 | ||
Patient characteristics | ||||
Age (mean (SD)) | 57.48 (12.63) | 56.28 (11.91) | 0.69 | 0.389 |
BMI (mean (SD)) | 26.95 (5.43) | 25.36 (4.26) | 0.162 | 0.199 |
Blood Type (%) | 0.054 | |||
A | 13 (59.1) | 21 (31.8) | 0.881 | |
AB | 3 (13.6) | 5 (7.6) | 0.51 | |
B | 1 (4.5) | 12 (18.2) | 0.200 | |
O | 5 (22.7) | 28 (42.4) | 0.062 | |
Donor age (mean (SD)) | 43.36 (14.74) | 39.47 (13.20) | 0.248 | 0.355 |
Sex = F (%) | 10 (45.5) | 17 (25.8) | 0.142 | 0.21 |
History of tobacco use = Y (%) | 6 (27.3) | 25 (37.9) | 0.519 | 0.885 |
Diabetes = Y (%) | 11 (50.0) | 18 (27.3) | 0.089 | 0.383 |
Cohort (%) | 0.115 | |||
Cedar-Sinai | 14 (63.6) | 29 (43.9) | 0.55 | |
Columbia | 1 (4.5) | 15 (22.7) | 0.27 | |
Pitié Salpêtrière | 7 (31.8) | 22 (33.3) | 0.99 | |
Cardiomyopathy | ||||
Ischemic = Y (%) | 8 (36.4) | 24 (36.4) | 1 | 0.268 |
Non-Ischemic (%) | 0.271 | |||
Adriamycin | 1 (4.5) | 0 (0.0) | 1 | |
Amyloid | 0 (0.0) | 2 (3.0) | 1 | |
Chagas | 0 (0.0) | 1 (1.5) | – | |
Congenital | 1 (4.5) | 0 (0.0) | 1 | |
Hypertrophic cardiomyopathy | 0 (0.0) | 1 (1.5) | – | |
Idiopathic | 11 (50.0) | 36 (54.5) | – | |
Myocarditis | 0 (0.0) | 1 (1.5) | 1 | |
Valvular heart disease | 1 (4.5) | 0 (0.0) | – | |
Viral | 0 (0.0) | 1 (1.5) | – | |
Transplant factors | ||||
PGD = Y (%) | 20 (90.9) | 22 (33.3) | < 0.001 | 0.019 |
Ischemic Time (min (SD)) | 154.45 (61.18) | 165.19 (57.73) | 0.459 | 0.048 |
Ventricular Assist Device = Y (%) | 5 (22.7) | 16 (24.2) | 1 | 0.953 |
Hemodynamics | ||||
PA Diastolic (mean (SD)) mmHg | 20.05 (8.08) | 20.74 (6.98) | 0.7 | 0.092 |
PA Systolic (mean (SD)) mmHg | 45.93 (15.03) | 43.49 (13.36) | 0.475 | 0.941 |
PA Mean (mean (SD)) mmHg | 31.78 (8.39) | 29.74 (8.77) | 0.341 | 0.687 |
CVP (mean (SD)) mmHg | 10.56 (4.95) | 9.44 (5.30) | 0.387 | 0.774 |
PCWP (mean (SD)) mmHg | 21.21 (8.13) | 19.52 (8.34) | 0.408 | 0.200 |
Lab values | ||||
Creatinine (mean (SD)) mg/dL | 1.32 (0.49) | 1.30 (0.98) | 0.942 | 0.160 |
INR (mean (SD)) | 1.73 (0.80) | 1.50 (0.55) | 0.135 | 0.063 |
TBili (mean (SD)) mg/dL | 0.83 (0.47) | 0.87 (0.50) | 0.744 | 0.102 |
Sodium (mean (SD)) mEq/L | 138.16 (4.03) | 136.90 (5.06) | 0.294 | 0.489 |
Medications | ||||
Antiarrhythmic Use = Y (%) | 15 (68.2) | 32 (48.5) | 0.175 | 0.200 |
Beta Blocker = Y (%) | 15 (68.2) | 39 (59.1) | 0.613 | 0.143 |
Inotrope = Y (%) | 7 (31.8) | 37 (56.1) | 0.085 | 0.176 |
Composite scores | ||||
CVP/PCWP (mean (SD)) | 0.54 (0.27) | 0.51 (0.27) | 0.659 | 0.355 |
MELD-XI (mean (SD)) | 7.19 (4.77) | 6.89 (4.27) | 0.788 | 0.116 |
