Table 1 GO category, GO pathways, corresponding p-values, and AR-DEGs.

Biological process

Regulation of autophagy

GO:0010506)

5.24E−09

PLEKHF1;BAD;ZC3H12A;TFEB;VDAC1;

PRKAB1;TRIM65

Positive regulation of autophagy

GO:0010508)

5.2E−08

PLEKHF1;BAD;ZC3H12A;TFEB;TRIM65

Positive regulation of cellular catabolic process

GO:0031331)

4.93E−07

PLEKHF1;BAD;ZC3H12A;TFEB;TRIM65

Positive regulation of cold-induced thermogenesis

GO:0120162)

4.29E−06

ADIPOQ;HSF1;CXCR4;PRKAB1

Positive regulation of metabolic process

GO:0009893)

7.87E−06

ADIPOQ;HSF1;CXCR4;PRKAB1

Macroautophagy

GO:0016236)

9.99E−06

GABARAPL1;CHMP4B;VDAC1;PRKAB1

Response to sodium arsenite

GO:1903935)

1.26E−05

HSF1;ZC3H12A

Cellular response to sodium arsenite

GO:1903936)

1.26E−05

HSF1;ZC3H12A

Cellular response to salt

GO:1902075)

1.89E−05

HSF1;ZC3H12A

Negative regulation of tumor necrosis factor production

GO:0032720)

1.95E−05

ADIPOQ;ZC3H12A;DICER1c

Molecular function

Low-density lipoprotein particle receptor binding

GO:0050750)

0.000315

HSPG2;AP2M1

Lipoprotein particle receptor binding

GO:0070325)

0.00047

HSPG2;AP2M1

Endoribonuclease activity

GO:0004521)

0.000694

ZC3H12A;DICER1

Regulatory RNA binding

GO:0061980)

0.000961

ZC3H12A;DICER1

Endonuclease activity

GO:0004519)

0.001559

ZC3H12A;DICER1

Kinase binding

GO:0019900)

0.001742

BAD;HSF1;VDAC1;PRKAB1

Protein kinase binding

GO:0019901)

0.002446

BAD;HSF1;VDAC1;PRKAB1

Ribonuclease activity

GO:0004540)

0.002595

ZC3H12A;DICER1

C-X-C chemokine receptor activity

GO:0016494)

0.005737

CXCR4

Intronic transcription regulatory region sequence-specific DNA binding

GO:0001161)

0.005737

HSF1

Cellular component

lysosome

GO:0005764)

7.4E−07

ARSA;PLEKHF1;RAB12;TFEB;CXCR4;

HSPG2;AP2M1

Lytic vacuole

GO:0000323)

0.000105

ARSA;PLEKHF1;RAB12;CXCR4

Lytic vacuole membrane

GO:0098852)

0.003419

PLEKHF1;TFEB;AP2M1

Lysosomal lumen

GO:0043202)

0.00436

ARSA;HSPG2

Endosome membrane

GO:0010008)

0.005917

PLEKHF1;RAB12;AP2M1

Lysosomal membrane

GO:0005765)

0.006172

PLEKHF1;TFEB;AP2M1

Nuclear stress granule

GO:0097165)

0.006881

HSF1

AP-2 adaptor complex

GO:0030122)

0.008023

AP2M1

Clathrin coat of endocytic vesicle

GO:0030128)

0.008023

AP2M1

Mitochondrial outer membrane

GO:0005741)

0.009136

BAD;VDAC1