Figure 1 | Scientific Reports

Figure 1

From: Intratumoral heterogeneity of c-KIT mutations in a feline splenic mast cell tumor and their functional effects on cell proliferation

Figure 1

Schematic representation of the structure of feline c-KIT gene and c-KIT protein. Boxes show the exon structure of feline c-KIT cDNA, and the numbers in each box indicate the exon number. The number above and below each box indicates the numbers of the first nucleotide and amino acid in each exon, respectively. Protein structure is shown below the DNA structure in gray line and gray boxes, as predicted from the amino acid sequence of feline c-KIT by InterPro (https://www.ebi.ac.uk/interpro/). Numbers below the protein structure indicate the amino acid numbers of each domain. D1–D5 refer to immunoglobulin domains. TM, transmembrane domain; JM, juxtamembrane domain; TK, tyrosine kinase domain. M537R and W854R indicate the point mutation in the TM domain and TK2 domain, respectively. Dotted boxes below the protein structure represent the mutations in exons 8 and 9. WT, wild type; Ins8, the insertional mutation in exon 8; Δ9, the deleted mutation in exon 9.

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