Table 1 Incidence of the histopathological findings of neoplastic lesions in the all organs excluding the lung and mediastinal lymph nodes.
Male | Female | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Exposure concentration (mg/m3) | 0 | 2 | 8 | 32 | 0 | 2 | 8 | 32 | ||
No. of animals examined | 25 | 25 | 25 | 25 | 25 | 25 | 25 | 25 | ||
Histopathological findings | ||||||||||
Stomach | ||||||||||
Squamous cell papilloma | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | ||
Liver | ||||||||||
Hepatocellular adenoma | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | ||
Harderian gland | ||||||||||
Adenoma | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | ||
Peritoneum | ||||||||||
Leiomyosarcoma | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | ||
Subcutis | ||||||||||
Hemangioma | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | ||
Hemangiosarcoma | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | ||
Spleen | ||||||||||
Hemangioma | 2 | 1 | 1 | 1 | 1 | 2 | 2 | 0 | ||
Hemangiosarcoma | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | ||
Pancreas | ||||||||||
Hemangioma | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | ||
Urinary bladder | ||||||||||
Hemangioma | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | ||
Uterus | ||||||||||
Hemangiosarcoma | 0 | 1 | 0 | 0 | ||||||
Brain | ||||||||||
Hemangiosarcoma | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | ||
Mediastinum | ||||||||||
Hemangiosarcoma | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | ||
Pleura | ||||||||||
Hemangiosarcoma | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | ||
Peritoneum | ||||||||||
Hemangiosarcoma | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | ||
All-site | ||||||||||
Hemangioma | 2 | 2 | 2 | 1 | 2 | 2 | 2 | 1 | ||
Hemangiosarcoma | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 2 | ||
Total tumor | 2 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||
