Figure 3 | Scientific Reports

Figure 3

From: Circ_0047339 promotes the activation of fibroblasts and affects the development of urethral stricture by targeting the miR-4691-5p/TSP-1 axis

Figure 3

The expression of circ_0047339/miRNA/TSP-1 interaction in urethral scar tissue. (A) We performed western blot to verify the expression of COL-1 and α-SMA in urethral scar tissue. (B) We confirmed the expression of the first nine differential circRNA in the chip microarray analysis by RT-qPCR. (C) The expression of TSP-1 in urethral scar tissue was verified by RT-qPCR. (D) The correlation between TSP-1 and circ_0047339. (E) Venn diagram. (F) The expression of let-7b-5p, miR-4691-5p, miR-766-5p and miR-550b-2-5p were characterized by RT-qPCR in urethral scar tissue. (G) Correlation analysis of TSP-1 and circ_0047339 with let-7b-5p, miR-4691-5p, miR-766-5p and miR-550b-2-5p. Blue represents positive correlation, and brown represents negative correlation. A larger absolute value of the r-value indicates a stronger correlation. *P < 0.05, **P < 0.01, ***P < 0.001, ns no significance.

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