Figure 6 | Scientific Reports

Figure 6

From: Aberrant expression of miR-133a in endothelial cells inhibits angiogenesis by reducing pro-angiogenic but increasing anti-angiogenic gene expression

Figure 6

Ingenuity Pathway Analysis of differentially expressed genes in endothelial cells expressing ectopic miR-133a-3p. (A,C) Bar plots showing enriched biological functions predicted by IPA in the category “Cardiovascular system development and function” (A) and “Cell Cycle”, and “DNA replication, recombination and repair” (C). Bar lengths are relative to enrichment significance, expressed as − log10(Benjamini–Hochberg adjusted P values). (B,D) Circular plots representing enriched biological functions detected in the categories “Cardiovascular system development and function” (B) and “Cell Cycle”, “DNA replication, recombination and repair” (D). Enriched biological functions are connected to the associated differentially expressed genes. FC, fold change. Activation z-score scale: blue repression; red, activation. LogFC scale: red, upregulated; blue, downregulated. Barplots were generated with R 3.6.3 (https://www.r-project.org). Circular plots were generated with GOplot 1.0.2 (https://wencke.github.io).

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