Figure 6 | Scientific Reports

Figure 6

From: Delivery and assessment of a CRISPR/nCas9-based genome editing system on in vitro models of mucopolysaccharidoses IVA assisted by magnetite-based nanoparticles

Figure 6

Effect of MLPs-attached CRISPR/nCas9 on the global profile of NO-derived species in MPS IVA fibroblasts. Mean of 4 experiments for GM01361 fibroblasts after transfection with CRISPR/nCas9-Donor AAVS1:GALNS plasmids (CRISPR/nCas9:Donor) using LP and MLPs as the delivery system. Note that untreated cells showed a significant increase in nitrites amounts compared to wild-type. LPS was used as positive control on wild-type cells. *p ≤ 0.05. Two-tailed Student's t-test.

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