Figure 1 | Scientific Reports

Figure 1

From: Lactococcus lactis engineered to deliver hCAP18 cDNA alleviates DNBS-induced colitis in C57BL/6 mice by promoting IL17A and IL10 cytokine expression

Figure 1

Effect of DNBS injection on weight loss and macroscopic score on experimental groups receiving recombinant L. lactis or not. (A) Experimental protocol for the DNBS-induced model of colitis in mice. Effects of LL-Probi-H1-empty, LL-Probi-H1-hCAP18, LL-pSEC:empty and LL-pSEC:hCAP18 on recovery from DNBS with respect to (B) body weight and (C) macroscopic score. Data represent mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, n = 24 mice per group for LL-Probi-H1:empty and LL-Probi-H1:hCAP18, n = 16 for LL-pSEC:empty and LL-pSEC:hCAP18, n = 20 mice for healthy control.

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