Figure 4 | Scientific Reports

Figure 4

From: Osteogenesis in human periodontal ligament stem cell sheets is enhanced by the protease-activated receptor 1 (PAR1) in vivo

Figure 4

(A) Ex-vivo histological qualitative analysis from H&E, Van Gieson, Masson’s Trichrome and Von Kossa stains from the 3 groups after a 2-month transplantation period in balb/c nude mice. Images at 10x and 20x. CTRL group displayed connective tissue characteristics with necrotic spots (gray arrows) and no bone formation was detected in this group for the 4 stains. Osteoblast clusters (black solid arrows) and blood vessels (red solid arrows) were detected in higher abundance in the OST group when compared with the other groups. The OST + PAR1 group showed greater osteocyte numbers (black dotted circle) and higher calcium deposits (B) (red dotted line).

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