Figure 2

TLR4 caused the damages of intestinal mucosal structure in CLP mouse by Hematoxylin–Eosin staining, including intestinal epithelium degeneration and shedding, villus atrophy and disordered arrangement. Compared to the Sepsis group, TAK-242 treatment had reduced the damages, with a smaller necrotic shedding tissue, small intestinal villi thickening.