Figure 1 | Scientific Reports

Figure 1

From: Hereditary E200K mutation within the prion protein gene alters human iPSC derived cardiomyocyte function

Figure 1

E200K and DS cardiomyocytes have altered electrophysiology. (a) Tropomyosin staining of the differentiated cardiomyocytes, scale bar = 100 µm. (b) Schematic showing measured parameters. (c) Representative traces for the control, E200K and DS cardiomyocytes (y axes are not equivalent but scaled to show detail). Graphs showing (d) peak to peak amplitude, (e) peak to peak duration, (f) field potential duration (corrected to RR interval; FPDc), (g) conduction velocity, (h) RR interval and (i) RR coefficient of variance (variability of the RR interval). Graphs show data points of each independent biological repeat ‘n’ with mean and SEM, *p < 0.05, **p < 0.01, and ***p < 0.001.

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