Figure 3

In-vitro activity of JBSNF-000028: Inhibition of recombinant (A) human, (B) mouse or (C) monkey NNMT as determined by fluorescence of an MNA derivative. (D) Inhibition of human NNMT as determined by LC/MS detection of MNA. (E) Inhibition of NNMT in U2OS cells as measured by LC/MS detection of MNA.