Figure 7
Efficacy of JBSNF-000028 in ob/ob model. (A) Body weight changes (%) and cumulative energy intake in ob/– control animals and ob/ob animals treated with vehicle or JBSNF-000028 at 50 mg kg−1. (B) Fed blood glucose and fed plasma insulin profile of ob/– control animals and ob/ob animals treated with vehicle or JBSNF-000028 at 50 mg kg−1. (C) Plasma triglycerides, plasma total cholesterol, plasma LDL cholesterol, MNA measurements in visceral WAT and s/c fat samples of ob/– control animals and ob/ob animals treated with vehicle or JBSNF-000028 at 50 mg kg−1. (D) OGTT profile, (E) Area under the curve (AUC), (F) plasma glucose levels at the time of the glucose bolus. Data are presented as mean ± s.e.m. *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001 when compared with ob/– control and $$$$p < 0.0001 when compared with ob/ob vehicle control. Two way ANOVA followed by Bonferroni’s post-hoc test (A, B, D); One way ANOVA followed by Bonferroni’s post-hoc test (C, E, F).
