Table 4 ADME, and safety profile of JBSNF-0000028.

From: Novel tricyclic small molecule inhibitors of Nicotinamide N-methyltransferase for the treatment of metabolic disorders

Parameter

JBSNF-0000028

Solubility (ÎĽM)

 > 200

Caco-2 permeability (nm/s)

1.05

Caco-2 Efflux ratio

4.90

Metabolic stability h/r/m/microsomes (% remaining)

90/95/86

CYP inhibition

 > 20 µM

Ames test

Negative

Micronucleus test

Negative

Selectivity panel

Cleana

  1. aSelectivity of JBSNF-0000028 against a panel of diverse targets is shown in Supplementary Table 1.
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