Table 1 Demographics and clinical characteristics of 102 dNENs. PPPD –pylorus preserving pancreatoduodenectomy. SSTA – somatostatin analogues. PRRT – peptide radiolabelled receptor targeted therapy.
Number of patients | 102 57 m/45f. |
Mean age at diagnosis | 62 (32–87) |
Location D1 | 63 (62%) |
D2 | 19 (19%) |
D3 | 3 (3%) |
D4 | 2 (2%) |
Unknown | 15 (15%) |
Grade 1 Ki 67 < 3% | 68 (67%) |
Grade 2 Ki 67 (3–20%) | 21 (21%) |
Grade 3 Ki 67 > 20% | 3 (3%) |
Unknown | 10 (10%) |
Size | Mean 16 mm (range 0.9–130 mm) Median 10 mm |
< 10 mm | 43 (42%) |
11-20 mm | 39 (38%) |
> 20 mm | 18 (18%) |
Unknown | 2 (2%) |
Subtype—Non-functioning | 87 (85%) |
Gastrinoma | 9 (9%) |
Carcinoid | 3 (3%) |
Paraganglioma | 1 (1%) |
Poorly differentiated NEC | 2 |
Stage I | 48 (47%) |
Stage II | 21 (21%) |
Stage III | 8 (8%) |
Stage IV | 25 (25%) |
Non-medical treatment | 83 patients |
Active surveillance | 36 (43%) |
Endoscopic resection | 17 (20%) |
Surgery | 30(36%) PPPD 4 |
Whipples 8 | |
Segmental resection 9 | |
Partial duodenectomy 9 | |
Synchronous liver mets resection 8 pts | |
Medical treatment | 25 patients |
SSTA’s | 23 (92%) |
Chemotherapy | 7 (28%) |
PRRT | 5 (20%) |
Functional imaging avidity | |
Gallium PET scan | 31/55(56%) |
FDG avidity | 8/39 (21%) |
