Table 2 Hazard ratios for cardiovascular events and deaths in the alfacalcidol group based on both ALP and PTH.

From: Effects of alfacalcidol on cardiovascular outcomes according to alkaline phosphatase levels in the J-DAVID trial

Subgroups

Fatal and non-fatal CV events

All-cause mortality

CV events and mortality

iPTH

ALP

HR* [95% CI]

P-value

HR* [95% CI]

P-value

HR* [95% CI]

P-value

46 pg/mL

183 U/L

1.54 [0.91–2.60]

0.11

0.99 [0.58–1.70]

0.98

1.14 [0.75–1.72]

0.54

234 U/L

1.33 [0.82–2.16]

0.25

0.89 [0.53–1.49]

0.65

1.03 [0.68–1.55]

0.90

296 U/L

1.18 [0.69–2.01]

0.54

0.90 [0.51–1.59]

0.71

1.00 [0.64–1.57]

0.99

85 pg/mL

183 U/L

1.38 [0.90–2.11]

0.14

1.20 [0.76–1.88]

0.44

1.15 [0.82– 1.62]

0.43

234 U/L

1.16 [0.80–1.66]

0.44

0.99 [0.67–1.45]

0.94

0.99 [0.73–1.35]

0.97

296 U/L

1.08 [0.72–1.61]

0.71

0.93 [0.61–1.43]

0.74

0.97 [0.69–1.35]

0.85

129 pg/mL

183 U/L

1.22 [0.66– 2.27]

0.52

1.47 [0.75–2.89]

0.26

1.16 [0.70–1.92]

0.56

234 U/L

0.99 [0.62–1.57]

0.96

1.11 [0.68–1.82]

0.67

0.96 [0.66–1.40]

0.82

296 U/L

0.98 [0.59–1.63]

0.93

0.97 [0.56–1.68]

0.91

0.94 [0.62–1.42]

0.76

  1. iPTH intact parathyroid hormone, ALP alkaline phosphatase, HR hazard ratio, CI confidence interval.
  2. *HR in the alfacalcidol group vs the control group at each specified iPTH and ALP values.