Table 2 Genetic background of AML patients and expression of OX40, OX40L.
From: Expression of the immune checkpoint modulator OX40 indicates poor survival in acute myeloid leukemia
Marker | Characteristics | N | Mutated/positive (mean + /− SD) | N | Unmutated/negative (mean + /− SD) | p value |
|---|---|---|---|---|---|---|
OX40 SFI | t(15;17) | 6 | 3.4 (4.1) | 63 | 3.6 (5.2) | 0.639 |
inv(16) | 4 | 2.2 (1.9) | 63 | 3.7 (5.3) | 0.525 | |
FLT3-ITD | 28 | 5.0 (5.8) | 36 | 2.8 (4.7) | 0.025 | |
FLT3-TKD | 5 | 1.7 (0.4) | 59 | 3.9 (5.4) | 0.950 | |
NPM1 | 24 | 5.8 (7.6) | 40 | 2.4 (2.5) | 0.131 | |
CEBPA | 6 | 1.7 (0.6) | 51 | 3.5 (4.7) | 0.876 | |
MLL-AF9 | 2 | 1.0 (0.2) | 59 | 3.4 (4.4) | 0.096 | |
IDH 2 | 6 | 2.8 (2.9) | 25 | 2.2 (2.4) | 0.484 | |
OX40% | t(15;17) | 6 | 26.3 (33.2) | 63 | 18.7 (25.1) | 0.297 |
inv(16) | 4 | 13.6 (22.9) | 63 | 20.3 (26.2) | 0.443 | |
FLT3-ITD | 28 | 28.7 (28.2) | 36 | 13.1 (23.4) | 0.020 | |
FLT3-TKD | 5 | 5.4 (7.5) | 59 | 26.6 (27.1) | 0.220 | |
NPM1 | 24 | 27.6 (30.2) | 40 | 14.5 (22.9) | 0.149 | |
CEBPA | 6 | 7.1 (9.0) | 51 | 19.3 (26.4) | 0.507 | |
MLL-AF9 | 2 | 2.1 (1.9) | 59 | 19.0 (25.2) | 0.331 | |
IDH 2 | 6 | 17.9 (22.1) | 25 | 14.2 (25.0) | 0.881 | |
OX40L SFI | t(15;17) | 6 | 3.5 (2.8) | 63 | 3.0 (5.7) | 0.025 |
inv(16) | 4 | 2.2 (1.1) | 63 | 3.1 (5.8) | 0.220 | |
FLT3-ITD | 28 | 3.3 (6.6) | 36 | 2.9 (5.0) | 0.516 | |
FLT3-TKD | 5 | 3.7 (5.1) | 59 | 3.1 (5.8) | 0.770 | |
NPM1 | 24 | 3.0 (6.4) | 40 | 3.2 (5.2) | 0.224 | |
CEBPA | 6 | 1.3 (0.6) | 51 | 3.5 (6.3) | 0.061 | |
MLL-AF9 | 2 | 1.1 (0.2) | 59 | 3.2 (5.9) | 0.268 | |
IDH 2 | 6 | 6.2 (12.3) | 25 | 4.1 (7.4) | 0.530 | |
OX40L % | t(15;17) | 6 | 40.6 (22.7) | 63 | 13.5 (2.2) | 0.004 |
inv(16) | 4 | 19.0 (16.6) | 63 | 14.8 (23.5) | 0.126 | |
FLT3-ITD | 28 | 15.1 (23.5) | 36 | 15.5 (23.6) | 0.977 | |
FLT3-TKD | 5 | 21.6 (26.3) | 59 | 14.9 (23.3) | 0.956 | |
NPM1 | 24 | 14.2 (22.8) | 40 | 16.1 (24.0) | 0.588 | |
CEBPA | 6 | 5.1 (10.2) | 51 | 17.5 (24.7) | 0.007 | |
MLL-AF9 | 2 | 2.19 (3.09) | 59 | 15.4 (23.4) | 0.245 | |
IDH 2 | 6 | 22.6 (33.5) | 25 | 23.9 (29.5) | 0.962 |
