Table 3 Top 20 predictors of overall survival identified by the gradient-boosted Cox proportional hazard model and SHAP values.

From: Machine learning models for identifying predictors of clinical outcomes with first-line immune checkpoint inhibitor therapy in advanced non-small cell lung cancer

Gradient-boosted Cox proportional hazard model

SHAP

ECOG performance status38

ECOG performance status38

Albumin serum mean39

Albumin serum mean39

Body weight slope38

Cough suppressants, excluding combinations with expectorants

PD-L1 percentage38

PD-L1 percentage38

Hematocrit mean41

Body weight slope38

Cough suppressants, excluding combinations with expectorants

Hematocrit mean41

Chloride mean41

Chloride mean41

Neutrophil per lymphocyte38

Age at index4

Lymphocyte count (fractionated) mean38

Neutrophil per lymphocyte38

Alkaline phosphatase (ALP) mean

Albumin serum slope39

Age at index4

Lymphocyte count (fractionated) mean38

Urea nitrogen mean

Metastasis site: bone/bone marrow

Albumin serum standard deviation39

Albumin serum standard deviation39

Albumin serum slope39

Body weight standard deviation38

White blood cell count mean

Alkaline phosphatase (ALP) mean39

Metastasis site: liver/bile duct

Total bilirubin serum mean

Body weight standard deviation38

Lymphocyte count (fractionated) slope38

Metastasis site: bone/bone marrow

Metastasis site: liver/bile duct

Lymphocyte count (fractionated) slope38

Sex female

Monocyte count mean

White blood cell count mean

  1. SHAP indicates directionality of the importance (bold: higher values indicate better overall survival; italics: lower values indicate better overall survival).
  2. ECOG, Eastern Cooperative Oncology Group; PD-L1, programmed cell death-ligand 1; SHAP, SHapley Additive exPlanation.