Figure 2
From: Prophylactic administration of miR-451 inhibitor decreases osteoarthritis severity in rats
Gross images, micro-CT, and histology from the prophylactic cohort of the miR-451-PI study. Gross images (A,C,E), 3D micro-CT rendering (B,D,F), medial and lateral micro-CT images (G–L). A shadow projection of the femur is included in the top corner of each micro-CT image with a red line to indicate the location each micro-CT image is taken from within the joint (G–L). Masson’s trichrome histology (M–R) and the respective zoomed-in images as depicted by the black box (S–X) for the normal control, NC-PI, and 451-PI groups, respectively. Scale bar: 500 μm. Subchondral bone (sub bone); medial (med); lateral (lat); arrows, areas of cartilage erosion or subchondral bone remodeling; arrowheads, abnormal cartilage remodeling; C, cartilage; FT, fibrotic tissue; asterisk, microfracture.
