Figure 1

Chemical structure (A) and the effects of COS (B–E) on the clinical symptoms in UUO-induced RF mice. Representative somatotype pictures of mice in each group (B). Diet changes (C). Water intake changes (D). Body weight changes (E). All values are represented as mean ± SD (n = 10 in each group). Superscript letters a and b designate significant differences. aP < 0.05 compared with the model group. bP < 0.01 compared with the model group.