Table 1 Effect of COS on alleviating kidney injury in UUO mice model.

From: Chitosan oligosaccharide alleviates renal fibrosis through reducing oxidative stress damage and regulating TGF-β1/Smads pathway

Indexes

Treatment

Normal

Model

Low-dose

High-dose

Positive

Obstructed kidney

0.172 ± 0.018b

0.523 ± 0.168

0.343 ± 0.041b

0.311 ± 0.042b

0.306 ± 0.09b

Non-obstructed kidney

0.170 ± 0.016

0.185 ± 0.022

0.173 ± 0.02

0.193 ± 0.016

0.184 ± 0.017

The ratio of the obstructed/non-obstructed kidney

1.010 ± 0.072b

2.842 ± 0.82

1.998 ± 0.217a

1.622 ± 0.279b

1.650 ± 0.421b

BUN (mmol/L)

1.434 ± 0.201b

1.700 ± 0.097

1.485 ± 0.161a

1.463 ± 0.124b

1.547 ± 0.163a

SCr (μmol/L)

37.101 ± 4.760b

75.297 ± 8.401

46.578 ± 5.929b

39.914 ± 12.802b

33.505 ± 6.929b

Tubulointerstitial injury score

0.000 ± 0.000b

8.333 ± 0.500

6.111 ± 0.782a

4.222 ± 0.833b

4.778 ± 1.302b

Percentage of the Masson

1.089 ± 0.196b

66.744 ± 3.926

51.644 ± 3.463a

30.267 ± 1.733b

40.111 ± 1.545b

  1. COS improve kidney injury in UUO mice model. All values are represented as mean ± SD (n = 10 in each group). Superscript letters a and b designate significant differences. aP < 0.05 compared with the model group. bP < 0.01 compared with the model group.