Table 1 Effect of COS on alleviating kidney injury in UUO mice model.
Indexes | Treatment | ||||
---|---|---|---|---|---|
Normal | Model | Low-dose | High-dose | Positive | |
Obstructed kidney | 0.172 ± 0.018b | 0.523 ± 0.168 | 0.343 ± 0.041b | 0.311 ± 0.042b | 0.306 ± 0.09b |
Non-obstructed kidney | 0.170 ± 0.016 | 0.185 ± 0.022 | 0.173 ± 0.02 | 0.193 ± 0.016 | 0.184 ± 0.017 |
The ratio of the obstructed/non-obstructed kidney | 1.010 ± 0.072b | 2.842 ± 0.82 | 1.998 ± 0.217a | 1.622 ± 0.279b | 1.650 ± 0.421b |
BUN (mmol/L) | 1.434 ± 0.201b | 1.700 ± 0.097 | 1.485 ± 0.161a | 1.463 ± 0.124b | 1.547 ± 0.163a |
SCr (μmol/L) | 37.101 ± 4.760b | 75.297 ± 8.401 | 46.578 ± 5.929b | 39.914 ± 12.802b | 33.505 ± 6.929b |
Tubulointerstitial injury score | 0.000 ± 0.000b | 8.333 ± 0.500 | 6.111 ± 0.782a | 4.222 ± 0.833b | 4.778 ± 1.302b |
Percentage of the Masson | 1.089 ± 0.196b | 66.744 ± 3.926 | 51.644 ± 3.463a | 30.267 ± 1.733b | 40.111 ± 1.545b |