Figure 6
Association between molecular relapse (tumor-specific VAF detection) and pathological Complete Response (pCR). An algorithm was created to assess association between pCR and observed molecular relapse using ctDNA VAF detection. The algorithm was considered positive if any of the variants in the custom micro-panel had a VAF > 0.005%. Each patient was assessed at each timepoint to determine positivity. If the ctDNA demonstrated molecular relapse, the timepoint was labeled in orange; ctDNA timepoints with no molecular relapse were labeled in green. Abbreviations: R = Clinical Remission; T0 = Baseline; T1 = Cycle 1 Day 3 (C1D3).
