Table 4 The plasma level of complement factor H variants by measuring multiple reaction monitoring assay and distribution, matching according to the genotype of complement factor H single nucleotide polymorphism rs800292.

From: Proteomic genotyping of SNP of Complement Factor H (CFH) Y402H and I62V using multiple reaction monitoring (MRM) assays

rs800292

GG

AG

AA

Amino acid

V

V/I

I

N

Total

72

57

17

Control

11

11

4

AMD

61

46

13

Plasma V concentration (ng/mL), mean ± SD

423.1 ± 152.2

225.2 ± 93.8

0.818 ± 1.017

Plasma I concentration (ng/mL), mean ± SD

3.1 ± 9.3

341.3 ± 183.5

683.4 ± 354.5

V/I ratio, mean ± SD

606.906 ± 641.983

0.711 ± 0.138

0.001 ± 0.002

CFH (V)/CFH (I) ratio

Total (control/AMD)

Total (control/AMD)

Total (control/AMD)

< 0.0089

0 (0/0)

0 (0/0)

17 (4/13)

0.0089–1.08

0 (0/0)

57 (11/46)

0 (0/0)

 > 1.09

72 (11/61)

0 (0/0)

0 (0/0)

Gene/MRM matching

100%

100%

100%

  1. V, valine; I, isoleucine; AMD, age-related macular degeneration; MRM, multiple reaction monitoring; SD, standard deviation.
Back to article page