Table 5 ANOVA and regression analysis of CCD responses of Study 3.

Model

0.0135*

< 0.0001*

< 0.0001*

< 0.0001*

< 0.0001*

A-Temperature

0.1193

0.7951

0.7228

0.6371

0.7146*

B-Time

0.8196

0.0045*

0.4004

0.7598

0.9525*

C-Solvent:Solid

0.0038*

< 0.0001*

< 0.0001*

< 0.0001*

0.0013*

AB

0.0733

–

0.0792

0.0129*

0.0200*

BC

–

–

–

–

–

AC

–

–

–

–

–

A²

–

< 0.0001*

–

0.0005*

< 0.0001*

B²

–

–

0.0070*

0.0164*

C²

–

0.0796

0.0377*

0.0002*

0.0001*

Lack of fit

0.4846

0.0676

0.0782

0.0813

0.1051*

R²

0.6973

0.9487

0.8931

0.9615

0.9117

R² adjusted

0.5476

0.9289

0.8396

0.9423

0.8555