Figure 1
From: Multi-trait genome-wide association study of opioid addiction: OPRM1 and beyond
Genomic SEM model and Manhattan plot. (a) A common factor (pg) gSEM model (using GenomicSEM) is fit with summary statistics from GENOA, MVP12-YP-SAGE, PGC, and Partners Health cohorts. Standardized estimates and standard errors are shown for each free parameter. Model fit is shown by a non-significant chi-square test, high Akaike information criterion (AIC, higher is better) and comparative fit index (CFI) equal to 1.0, and low standardized root mean squared root (SRMR) values (ideally < 0.05). (b) Manhattan plot for gSEM results with summary statistics from GWAS from each cohort. Bonferroni correction was used to correct for multiple comparisons; associations with P < 2 × 10–8 (indicated by horizontal black bar) were genome-wide significant (top SNP highlighted in red).
