Figure 4
From: Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxicity in Drosophila
Effects of age and the microbiome on APAP-induced mortality. Susceptibility of 5, 20, and 30-day old (A) male and (B) female flies to APAP induced mortality. Log-Rank test p < 0.0001, n = 60. (C) Survival of germ-free (GF) and conventional (CV) Drosophila exposed to 100 mM APAP. (D) Effect of antibiotic-mediated depletion of the microbiome on susceptibility to APAP toxicity. Log-Rank test p < 0.0001, n = 60.
