Table 3 Malignancy Risk Stratified by Degree of Hypoechogenicity and Predominant Echogenicity According to Composition and suspicious Features.

From: Malignancy risk stratification of thyroid nodules according to echotexture and degree of hypoechogenicity: a retrospective multicenter validation study

Echogenicity

All

Nodules with suspicious featuresa

Nodules without suspicious featuresa

No. of malignant nodules, N (%)

No. of nodules, N (%)

Malignancy risk (%)

No. of malignant nodules, N (%)

No. of nodules, N (%)

Malignancy risk (%)

No. of malignant nodules, N (%)

No. of nodules, N (%)

Malignancy risk (%)

All

Marked hypoechogenicity

204 (18.7)

315 (5.6)

64.8

178 (25.1)

228 (15.1)

78.1

26 (6.9)

87 (2.1)

29.9

Moderate hypoechogenicity

340 (31.2)

705 (12.6)

48.2

261 (36.8)

370 (24.5)

70.5

79 (20.8)

334 (8.2)

23.7

Mild hypoechogenicity

234 (21.5)

994 (17.7)

23.5

138 (19.4)

316 (21.1)

43.7

96 (25.3)

677 (16.6)

14.2

Iso- or hyperechogenicity

311 (28.6)

3587 (64.0)

8.7

133 (18.7)

594 (39.4)

22.4

177 (47.0)

2989 (73.1)

5.9

Total

1089 (100.0)

5601 (100.0)

19.4

710 (100.0)

1508 (100.0)

47.1

378 (100.0)

4087 (100.0)

9.2

Solid

Marked hypoechogenicity

201 (22.4)

304 (10.0)

66.1

176 (28.0)

224 (20.7)

78.6

25 (9.3)

80 (4.1)

31.3

Moderate hypoechogenicity

312 (34.8)

596 (19.6)

52.3

244 (38.8)

333 (30.8)

73.3

68 (25.4)

263 (13.4)

25.9

Mild hypoechogenicity

192 (21.4)

660 (21.7)

29.1

116 (18.4)

223 (20.6)

52.0

76 (28.4)

437 (22.3)

17.4

Iso- or hyperechogenicity

192 (21.4)

1481 (48.7)

13.0

93 (14.8)

300 (27.8)

31.0

99 (36.9)

1181 (60.2)

8.4

Total

897 (100.0)

3041 (100.0)

29.5

629 (100.0)

1080 (100.0)

58.2

268 (100.0)

1961 (100.0)

13.7

Partially cystic

Marked hypoechogenicity

3 (1.6)

11 (0.4)

27.3

2 (2.5)

4 (0.9)

50.0

1 (0.9)

7 (0.3)

14.3

Moderate hypoechogenicity

28 (14.6)

109 (4.3)

25.7

17 (21.0)

37 (8.6)

45.9

11 (9.9)

72 (3.4)

15.3

Mild hypoechogenicity

42 (21.9)

334 (13.0)

12.6

22 (27.2)

93 (21.7)

23.7

20 (18.0)

241 (11.3)

8.3

Iso- or hyperechogenicity

119 (62.0)

2106 (82.3)

5.7

40 (49.4)

294 (68.7)

13.6

79 (71.2)

1812 (85.0)

4.4

Total

192 (100.0)

2560 (100.0)

7.5

81 (100.0)

428 (100.0)

18.9

111 (100.0)

2132 (100.0)

5.2

  1. aSuspicious US features include punctuate echogenic foci, nonparallel orientation (taller than wide) and irregular shape.