Figure 3
Heatmap of predicted candidate epitopes for CD8 T cells. Each peptide is represented in the y-axis. The values displayed in the heatmaps are the percentile ranks for each peptide, when binding each of the 27 most common Class I alleles (x-axis). Lower percentile ranks values, closer to zero, corresponding to darker colors ranging from light purple to dark purple/black, show stronger binder epitopes (PR < 0.5) for the purpose of this study. The values in light pink close to PR = 1.0, in contrast, are considered weak binder or non-binders epitopes. In addition, the alleles in x axis are sorted by their frequencies in Word Population in decreasing order from left to right. Furthermore, each row informs the degree of promiscuity of each respective epitope. Top heatmap includes the predicted epitopes that have already been confirmed by biological assays, and bottom heat map includes the predicted epitopes that are novel.
