Figure 6
Weighted gene coexpression analysis in Lithospermum officinale. (A) Pearson correlation (PCC) of identified modules with each treatment. Each row of the heatmap depicts a single module of clustered genes with dark red and blue colours depicting strong positive and negative correlations, respectively. Numbers on the right represent the total number of genes coexpressed together in the respective module and each colour on the left represents an individual cluster of genes identified by WGCNA. (B) GO enrichment analysis of molecular functions of genes coexpressed with LePGT1 in the red subnetwork (n = 243) and LeSAT1 in the light-yellow module (n = 49) after filtering for gene significance (GS > 0.7) and module membership (> 0.7). The heatmap corresponds to the average GS of each GO category to the shikonin producing condition. Numbers on the right correspond to the number of genes in the respective GO term. (C) Expression levels of genes involved in the β-oxidative benzenoid pathway. Genes coexpressed together with LePGT1 in the red subnetwork are highlighted in red.
