Figure 6

Sex-dependent differences in ASD v. NT populations. (a) Effect sizes and q-values from random-effects models investigating the associations between different taxa and sex (female: positive direction, male: negative direction) in the ASD compared to NT groups are plotted. (b) Models investigating ASD-associated taxa (NT: positive direction, ASD: negative direction) in either males or females are also plotted. The color, transparency, and size of each point denotes the taxonomic rank of the taxon, the significance of the model, and the number of datasets included in the model, respectively. Horizontal dotted line indicates significance threshold (q = 0.05). Significant models are labelled by the taxon investigated except for strain-level results. These models are reported in Supplementary file 1: Table S7.