Figure 7 | Scientific Reports

Figure 7

From: Angiogenic stem cell delivery platform to augment post-infarction neovasculature and reverse ventricular remodeling

Figure 7

Experimental technique and protocol timeline. (A) A schema illustrating induction of myocardial infarction (MI) by ligating the left anterior descending coronary artery permanently and smooth muscle cell (SMC)-endothelial progenitor cell (EPC) bi-level cell sheet transplantation technique via a left thoracotomy approach. Created with BioRender.com. (B) Pictures of the operated rats of three groups: transplantation of SMC-EPC bi-level cell sheet (cell sheet group), no treatment (untreated control group), or a sham operation (a positive control). (C) Pictures of the cell sheet transplantation onto the ischemic area of the heart. (D) Timeline of the experimental protocol. USPIO, ultrasmall superparamagnetic iron oxide; MRI, magnetic resonance imaging; MEMRI, manganese-enhanced magnetic resonance imaging. Created with BioRender.com.

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