Figure 1
From: EphrinA4 mimetic peptide impairs fear conditioning memory reconsolidation in lateral amygdala
Injection of ephrinA4 mimetic peptide into the LA before memory retrieval impaired memory reconsolidation. (a) A molecular model of pep-ephrinA4 peptide bound to EphA4. (b) Rats were trained for fear conditioning and 24 h afterward injected with pep-ephrinA4 30 min before fear memory reactivation (CS presentation) and the effect on fear memory was studied a day later. The pep-ephrinA4 (n = 15) and control solution (n = 12) microinjected rats were not significantly different in freezing response to the CS during memory reactivation (p = 0.792). (c) Microinjection of pep-ephrinA4 30 min before fear memory retrieval impaired long-term fear memory tested 24 h afterward compared to control injected rats (F(1,25) = 5.473, p = 0.028). (d) Description of cannula tip placements.
