Figure 2
From: EphrinA4 mimetic peptide impairs fear conditioning memory reconsolidation in lateral amygdala
Injection of pep-ephrinA4 before fear conditioning impairs fear memory tested 1 h after memory reactivation. (a) Rats were trained for fear conditioning and 24 h afterward injected with pep-ephrinA4 30 min before fear memory reactivation (CS presentation) and the effect on fear memory was studied an hour later. The pep-ephrinA4 (n = 10) and control solution (n = 9) microinjected rats were not significantly different in freezing response to the CS during memory reactivation (p = 0.518). (b) Microinjection of pep-ephrinA4 30 min before fear memory retrieval impaired fear memory tested 1 h afterward compared to control injected rats (F(1,17) = 8.921 p = 0.008). (c) Description of cannula tip placements.
