Figure 2 | Scientific Reports

Figure 2

From: Novel Venetin-1 nanoparticle from earthworm coelomic fluid as a promising agent for the treatment of non-small cell lung cancer

Figure 2

Apoptotic and necrotic activity of Venetin-1 in A549 cells assessed with the Annexin V/PI staining assay. Panel (A) shows representative dot plots of A549 control cells (without incubation with Venetin-1) after double staining with Annexin V-FITC and PI. Panel (B) shows the effects of incubation with Venetin-1 (125 µg/mL) for 72 h on cell apoptosis in A549 cells. The cells were classified as viable cells (lower left square), early apoptotic cells (lower right square), late apoptotic cells (upper right square), and necrotic cells (upper left square). Representative images of three independent experiments are shown. Venetin-1 had a necrotic and apoptotic effect on the A549 cells. The rate of necrosis as well as early and late apoptosis in the Venetin-1-treated A549 cells was higher by 5%, 3%, and 22.13%, respectively, than in the control.

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