Figure 3
From: A living biobank of canine mammary tumor organoids as a comparative model for human breast cancer
The genetic landscape of CMT is conserved in patient-derived organoids. (a) Overview of somatic mutations of 21 CMTs for 29 mutated genes, with differentiation between simple and complex carcinomas. Six mutation types are represented according to the color legend. Point mutations of the corresponding organoids for the mentioned gene (PIK3CA, AKT1, TP53, KRAS) are represented (light blue lines). (b) Log R ratios markers on chromosome 27 for matched pair CMT-25-C1/ORG-25-C1. Note the conservation of the copy number variation in the organoid line. See also Supplementary Figure S3A.
