Figure 1 | Scientific Reports

Figure 1

From: Naturally-aged microglia exhibit phagocytic dysfunction accompanied by gene expression changes reflective of underlying neurologic disease

Figure 1

Aged microglia have reduced phagocytic capacity. Brains from female young (2 months) and old (19 months) mice (n = 3) were processed and live CD45 intermediate CD11b+ cells (microglia) were assessed for phagocytic capacity. (a) Cells were incubated with 0.5 μM of fluorescent fibril Aβ42 or medium (control) for 1 h and phagocytosis was assessed by flow cytometry, images made using ©BioRender - biorender.com. (b–c) Representative flow plots of 1 replicate of 4 are shown and mean ± s.e.m % of microglia showing phagocytosis of fluorescent Aβ42 are graphed *p ≤ 0.05, Student’s t Test.

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