Table 2 Average reversal score predicted anti-SARS-CoV-2 compounds in vitro efficacy testing.

From: Elucidating host cell response pathways and repurposing therapeutics for SARS-CoV-2 and other coronaviruses

Compound

IC50 (μM)

CC50 (μM)

SI index

AZD-1208

27.34

 > 50

1.83

Sitagliptin

 > 50

 > 50

1.00

SR-2640 hydrochloride

24.23

 > 50

2.06

Levetiracetam

 > 50

 > 50

1.00

Meclofenamic acid sodium salt

35.13

 > 50

1.42

Chloroquine

11.29

 > 150

13.29

Lopinavir

12.63

 > 50

3.96

Remdesivir

8.58

 > 50

5.83

  1. IC50, CC50, and SI index were calculated of each compound in SARS-CoV-2 infected in Vero cells. . No compound exhibited reasonable anti-SARS-CoV-2 activities due to high IC50 across board.
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