Table 6 Relationship of polymorphisms with TREML4 mRNA expression.

From: TREML4 polymorphisms increase the mRNA in blood leukocytes in the progression of atherosclerosis

Polymorphism

TREML4 mRNA expression

p-value

Non-expression

Expression

p-value

Low

High

rs2803495 A/G

N = 168

N = 157

N = 79

N = 78

Genotypes (%)

AA

94.6 (159)

68.8 (108)

 < 0.001

65.8 (52)

71.8 (56)

0.419

(Codominant)

AG

5.4 (9)

31.2 (49)

34.2 (27)

28.2 (22)

GG

0.0 (0)

0.0. (0)

0.0 (0)

0.0 (0)

(Dominant)

AA

94.6 (159)

68.8 (108)

 < 0.001

65.8 (52)

71.8 (56)

0.419

AG + GG

5.4 (9)

31.2 (49)

34.2 (79)

28.2 (22)

Alleles (%)

A

100.0 (168)

100 (157)

 < 0.001

100.0 (79)

100 (78)

0.558

G

5.4 (9)

31.2 (49)

34.2 (27)

28.2 (22)

rs2803496 C/T

 

N = 167

N = 157

 

N = 79

N = 78

 

Genotypes (%)

TT

95.2 (159)

65.6 (103)

 < 0.001

82.3 (65)

48.7 (38)

 < 0.001

(Codominant)

CT

4.2 (7)

30.6 (48)

15.2 (12)

46.2 (36)

CC

0.6 (1)

0.6 (6)

2.5 (2)

5.1 (4)

(Dominant)

TT

95.2 (159)

65.6 (103)

 < 0.001

82.3 (65)

48.7 (38)

 < 0.001

CT + CC

4.8 (8)

34.4 (54)

17.7 (14)

51.3 (40)

Alleles (%)

T

99.4 (166)

96.17 (151)

 < 0.001

97.4 (77)

94.8 (74)

0.0014

C

4.79 (8)

34.39 (54)

17.7 (14)

51.3 (40)

  1. Number of subjects in parenthesis. Frequencies were compared by the Chi-Squared test. p-values refer to comparisons among genotype frequencies of the different models and among allelic frequencies. < 10% of all samples did not have their genotype detected. ‘Non-expression’, mRNA TREML4 not expressed; ‘Expression’, mRNA TREML4 expressed. ‘Low expression’, TREML4 mRNA expression below the median value; ‘High expression’, TREML4 mRNA expression above median value.
  2. Significant values are in bolditalics.
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