Table 2 Meta-analysis sentinel variants for smoking initiation (SI) and smoking cessation (SC).

From: Genetic insights into smoking behaviours in 10,558 men of African ancestry from continental Africa and the UK

Trait

rsID

CHR

POS

EA

NEA

OR

CI

P-value

I2

Direction of effect

AFR_EAF

EUR_EAF

SI

rs116934871

1

12,772,253

A

G

0.810

[0.742–0.884]

3.57 × 10–6

0

−/−/−

0.149

0.000

 

rs114828540

4

6,488,077

C

G

1.530

[1.297–1.804]

5.91 × 10–7

0

+/+/+

0.028

0.000

 

rs75104774

7

156,210,294

T

C

1.530

[1.273–1.839]

4.77 × 10–6

4.962

+/+/+

0.027

0.000

 

rs10160111

10

44,936,177

T

C

1.465

[1.252–1.715]

2.68 × 10–6

0

+/+/+

0.033

0.001

 

rs11636198

15

47,879,004

C

A

0.859

[0.808–0.913]

1.70 × 10–6

0

−/−/−

0.277

0.553

 

rs74019935

16

51,217,700

T

A

0.822

[0.762–0.888]

7.27 × 10–7

0

−/−/−

0.169

0.013

 

rs4808946

19

15,193,912

C

T

1.175

[1.106–1.249]

1.78 × 10–7

0

+/+/+

0.595

0.873

SC

rs12443715

16

55,782,924

A

G

1.377

[1.205–1.572]

2.97 × 10–6

0.641

+/+/+

0.148

0.711

  1. rsID rs number, CHR chromosome, POS b37 position, EA effect allele, NEA non-effect allele, OR odds ratio, CI 95% confidence interval.
  2. I2: percentage of total variation across studies due to heterogeneity.
  3. Direction of effect: in order, AWI-Gen, UKB-AFR, UGR.
  4. AFR_EAF: effect allele frequency in AFR 1000GP30.
  5. EUR_EAF: effect allele frequency in EUR 1000GP30.
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