Figure 2 | Scientific Reports

Figure 2

From: The sleep EEG envelope is a novel, neuronal firing-based human biomarker

Figure 2

Coupling between EEG envelope in the cortical surface and MUA within the adjacent cortex in NREM sleep. (A) Cross-correlation of the two signals. The horizontal axis indicates time lags, the vertical axis indicates IME channel (N = 23, deeper channels shown at the bottom), while the color axis indicates correlation coefficients. Black outlines show statistically significant results after FDR correction. (B) Magnitude-squared coherence between the two signals. Overlain lines represent individual IME channels. Because of the large number of channels and no substantial between-channel differences, no particular pattern in color coding was used. Dots indicate statistical significance after FDR correction on the corresponding channel. Deeper channels are shown at the top. (C) Mean MUA amplitude (in within-segment z-scores) by ECoG envelope phase bins. Dots indicate statistical significance after FDR correction on the corresponding channel. A sinusoid is overlain in the low delta subplot for illustration. On (B,C), for better visibility only IME channels are shown where at least one data point reached significance.

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