Figure 3 | Scientific Reports

Figure 3

From: Peripheral T cell cytotoxicity predicts the efficacy of anti-PD-1 therapy for advanced non-small cell lung cancer patients

Figure 3

Relationship between the peripheral T cell profile and severe adverse events (AEs). (A) A CITRUS analysis of pre-treatment samples comparing severe AEs (n = 8) versus non-severe AEs (n = 35). The abundance of the cluster significantly differed between the groups, as shown in the CITRUS cluster tree. (B) The abundance summary plot of the cluster that was significantly different between severe AEs and non-severe AEs. (C) Phenotype histograms of the cluster that increased in patients with severe AEs. (D) A comparison of the CD45RA+CD25+/CD4+ T cell ratio between severe AEs (n = 8) and non-severe AEs (n = 35). Each dot represents one patient. Data represent the mean ± standard error of the mean (SEM). The significance of differences was assessed using the Mann–Whitney's U test. (E) Receiver operating characteristic (ROC) curves for the CD45RA+CD25+/CD4+ T cell ratio to differentiate patients with severe AEs from those with non-severe AEs. AE, adverse event; AUC, area under the curve.

Back to article page