Figure 2 | Scientific Reports

Figure 2

From: Author Correction: Inhibitory effects of dopamine receptor D1 agonist on mammary tumor and bone metastasis

Figure 2

Inhibitory effects of A77636 on the migration of MD231 cells. The single and double asterisks indicate p < 0.05 and p < 0.01, respectively. (A) Dose-dependent suppression of cellular migration in response to 2, 5, and 10 μM A77636. Of note, CN = control. (B) Partial silencing of dopamine receptor D1 (DRD1) with DRD1 siRNA. (C, D) Wounded area with and without DRD1 siRNA in the presence and absence of 10 μM A77636. The double asterisk indicates p < 0.01. (E, F) FRET-based activities of RhoA and Rac1 GTPases, respectively, in response to 10 μM A77636. (G) Stationary FRET-based baseline activities of RhoA and Rac1 GTPases in the absence of A77636. (H) Rac1 activity after 1 h treatment with 1, 5, and 10 μM A77636. (I) FRET-based RhoA and Rac1 activities in the presence and absence of DRD1 siRNA in response to 10 μM A77636.

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