Figure 6 | Scientific Reports

Figure 6

From: Tumor suppressor DEAR1 regulates mammary epithelial cell fate and predicts early onset and metastasis in triple negative breast cancer

Figure 6

Simplified graphical model of DEAR1 regulation of luminal differentiation via TGF-β dependent and indepdendent mechanisms of SNAI2 inhibition. Top: DEAR1 inhibits SNAI2 (red pathway) by direct binding and uibiquitination, as well as by blocking SNAI2 transcription by binding and ubiquitinating upstream activator SMAD3 that is activated by TGF-β (green pathway). Bottom: Shifts in luminal differentiation dynamics or state occupancies (as depicted by arrow sizes, where larger size indicates higher likelihood) of luminal progenitors (blue), toward incomplete basal-like (green) or mature luminal cells (pink), depending on the presence (black) or absence (gray) of DEAR1,SNAI2, and TGF-β. The figure was created using Adobe Illustrator 2020 (Version 24.2.3), https://www.adobe.com/products/illustrator.html.

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