Table 1 Demographic characteristics.

From: Single-dose pharmacokinetics, safety, and tolerability of the dual endothelin receptor antagonist aprocitentan in subjects with moderate hepatic impairment

 

Moderate hepatic impairment (n = 8)

Healthy subjects (n = 9)

Sex (M:F)

7:1

8:1

Age (years)

60.6 (8.4)

61.1 (9.0)

Weight (kg)

80.3 (12.6)

77.9 (11.2)

Height (cm)

174 (5.6)

172 (7.7)

BMI (kg/m2)

26.5 (3.8)

26.2 (3.2)

Child–Pugh score*

Score 7

6 (75.0)

 

Score 8

2 (25.0)

 
  1. Data are expressed as arithmetic mean (SD), as a ratio for sex, or as n for Child–Pugh score (%).
  2. BMI body mass index, F female, M male, n number of subjects, SD standard deviation.
  3. *Calculated at screening.
Back to article page