Table 1 List of the 44 confirmed hit molecules retrieved from the HTS campaign as potential N-protein ligands.
Compound | IC50 (µM) | + Error* | − Error* |
|---|---|---|---|
Chebulinic acid | 0.2 | 0.0 | 0.0 |
L-Chicoric acid | 0.5 | 0.1 | 0.1 |
Punicalagin | 0.7 | 0.1 | 0.0 |
Punicalin | 0.7 | 0.1 | 0.1 |
Suramin | 0.8 | 0.1 | 0.1 |
Tannic acid | 1.4 | 0.2 | 0.2 |
Chlorophyllin B | 2.2 | 0.2 | 0.3 |
Corilagin | 2.4 | 0.5 | 0.4 |
4,5-Dicaffeoylquinic acid | 3.0 | 0.5 | 0.3 |
Methyl Blue | 4.2 | 0.3 | 0.3 |
Embelin | 5.0 | 0.9 | 0.7 |
Linaclotide | 5.5 | 0.6 | 0.5 |
Isochlorogenic acid A | 5.5 | 1.0 | 0.8 |
Sennoside A | 5.7 | 0.8 | 0.7 |
Lusutrombopag | 6.0 | 0.6 | 0.5 |
(R)-(-)-Gossypol acetic acid | 6.4 | 0.4 | 0.4 |
Idasanutlin | 6.5 | 0.7 | 0.6 |
Sulfamerazine | 6.5 | 0.9 | 0.8 |
Eltrombopag | 7.1 | 0.9 | 0.9 |
Gossypol acetic acid | 7.1 | 0.5 | 0.4 |
IOWH-032 | 7.7 | 0.9 | 0.8 |
Anacardic Acid | 7.7 | 0.9 | 0.7 |
Pranlukast (hemihydrate) | 7.8 | 1.1 | 1.0 |
Eltrombopag | 8.1 | 1.0 | 0.9 |
Succinobucol | 8.1 | 0.6 | 0.5 |
RNPA1000 | 9.6 | 1.8 | 1.4 |
TMC647055 | 10.0 | 1.2 | 1.0 |
Montelukast | 10.3 | 1.1 | 1.0 |
Micafungin | 10.4 | 0.9 | 0.8 |
Zafirlukast | 10.4 | 1.6 | 1.4 |
Resazurin | 10.5 | 1.7 | 1.4 |
Verteporfin | 10.8 | 3.4 | 2.6 |
Chlorophyllin A | 10.8 | 1.2 | 1.0 |
Surfactin | 11.1 | 1.5 | 1.3 |
Pentagalloylglucose | 11.6 | 1.9 | 1.7 |
Hexachlorophene | 13.0 | 1.6 | 1.3 |
Ertapenem sodium | 13.8 | 1.4 | 1.3 |
MK 0893 | 14.4 | 1.1 | 0,9 |
Butenafine | 15.7 | 1.3 | 1.2 |
Oleic acid | 15.7 | 0.9 | 0.8 |
Simeprevir | 16.5 | 0.9 | 0.9 |
Sofalcone | 18.5 | 1.6 | 1.5 |
Bithionol | 23.0 | 5.6 | 4.6 |
Gallic acid | 23.3 | 3.3 | 2.9 |
