Figure 11 | Scientific Reports

Figure 11

From: Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRASG12D inhibitors for cancer therapy

Figure 11

Comparative RMSD, RMSF and RoG plots of the hit compounds, MRTX1133 and unbound (holo) KRASG12D protein. (A) Shows the binding site RMSD elicited by the binding of the hit compounds. (B) Depicts the global stability of KRASG12D upon compounds binding. (C) Shows the residual fluctuations exhibited by the global protein residues during the simulation period. Highlights (deep yellow) show the switches regions. (D) Shows the RoG exhibited by the global protein. The bound conformations are contrasted to the unbound (Holo).

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