Figure 8 | Scientific Reports

Figure 8

From: Characterization of the binding of MRTX1133 as an avenue for the discovery of potential KRASG12D inhibitors for cancer therapy

Figure 8

(A) Superimposition of KRASG12D complexed with ZINC78453217, ZINC70875226, ZINC64890902 and MRTX1133. Insert shows the binding orientation of each inhibitor at 100 ns, 300 ns, and 450 ns. (B) Comparative inhibitor stability plots using RMSD metrics for ZINC78453217, ZINC70875226, ZINC64890902 and MRTX1133. (C) Comparative inhibitor SASA plots of ZINC78453217, ZINC70875226, ZINC64890902 and MRTX1133.

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