Figure 1 | Scientific Reports

Figure 1

From: Loss of SATB2 expression correlates with cytokeratin 7 and PD-L1 tumor cell positivity and aggressiveness in colorectal cancer

Figure 1

Histological slides showing colorectal carcinoma (CRC), hematoxylin–eosin (HE) stain, and immunohistochemistry, magnification 20×: (a) conventional adenocarcinoma with strong nuclear SATB2 positivity, CK7 negativity, and PD-L1 positivity in immune cells and negativity in tumor cells; (b) conventional adenocarcinoma with SATB2 negativity (staining in ca 1% tumor cells), strong cytoplasmic CK7 expression in 100% tumor cells, and strong membranous PD-L1 expression in ca 60% tumor cells; (c) conventional adenocarcinoma with SATB2 negativity, strong cytoplasmic CK7 positivity in 100% tumor cells, and PD-L1 negativity; (d) signet ring cell carcinoma with intracellular and extracellular mucin production showing SATB2 negativity (weak staining in ca 20% tumor cells), CK7 negativity, and PD-L1 negativity.

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