Figure 11 | Scientific Reports

Figure 11

From: Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish

Figure 11

Heatmap representing fluoxetine effects in animals on brain genes expressed in a similar direction in the sets deemed ‘enriched' using Fisher’s meta-analysis57 on maximal cliques (MCs) Gene Set Enrichment Analysis (GSEA) data for major depressive disorder (MDD) vs. human control or chronic unpredictable stress (CUS) vs. control rat and zebrafish data, mapped to 1:1:1 human orthologue using the HomoloGene database59 (Experiment 4; www.ncbi.nlm.nih.gov/homologene). Data are presented as mean log2 fold change.

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