Figure 2 | Scientific Reports

Figure 2

From: Evolutionarily conserved gene expression patterns for affective disorders revealed using cross-species brain transcriptomic analyses in humans, rats and zebrafish

Figure 2

Venn diagrams for differentially expressed (DE) genes or enriched gene sets (GSEA, gene set enrichment analysis) using similar raw RNA-seq data counts comparing subiculum in human major depressive disorder (MDD) vs. control, hippocampi in rats exposed to chronic unpredictable stress (CUS) vs. unexposed controls, and in zebrafish CUS-exposed vs. unexposed control whole brain samples, using 1:1:1 orthologues from the HomoloGene Map59 (Experiment 1, see the “Methods” section for details). Overall, these direct species-to-species comparisons revealed no common DE genes and very few common DE gene sets.

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